DEP® cabazitaxel

DEP® cabazitaxel is Starpharma’s detergent-free version of cancer drug, Jevtana®, which is marketed by Sanofi Aventis to treat advanced prostate cancer, and is also under clinical development for a range of other cancer types, including testicular, ovarian, breast, bladder, and head and neck. Jevtana® sales are estimated to reach approximately US$500 million this year.

DEP® cabazitaxel is the second product from Starpharma’s DEP® platform to enter the clinic, and follows DEP® docetaxel, which delivered positive phase 1 clinical results in 2017 and has progressed to phase 2. The reproducible benefits observed for DEP® docetaxel and DEP® cabazitaxel in preclinical models include decreased bone marrow toxicity and enhanced efficacy, and in both cases DEP® has also allowed for a detergent-free formulation resulting in significant additional benefits for patients.

Starpharma’s DEP® platform was utilised to create DEP® cabazitaxel, a detergent free version of cancer drug Jevtana®. Jevtana® is a leading oncology agent which is used to treat advanced prostate cancer and also under development for other cancers including breast cancer, bladder cancer and head and neck cancer. The current (non-dendrimer) formulation product has US Food and Drug Administration (FDA)-mandated ‘black box’ warnings in relation to neutropenia, which is a major dose limiting side effect, and sever hypersensitivity (e.g. anaphylaxis) resulting from the polysorbate 80 detergent used in its formulation.

DEP® cabazitaxel significantly outperformed Jevtana® in a human breast cancer model with respect to both level and duration of anti-cancer activity and survival, whilst protecting against the development of neutropenia, which is a serious side effect for Jevtana®.