DEP® posters showcased at AACR 2020
Four DEP® products were featured in five poster presentations at the 2020 Annual American Association for Cancer Research Annual Meeting in June 2020. These include three posters featuring AstraZeneca’s first DEP® oncology product AZD0466, and two posters which showcase Starpharma’s three phase 2 products, DEP® docetaxel, DEP® cabazitaxel and DEP® irinotecan.
These posters highlight the significant improvement in therapeutic index delivered to AZD0466 through the application of the DEP® technology, enabling its progression into the clinic. The posters also highlight the potent and broad ranging anti-cancer activity of AZD0466 which results from the dual Bcl2 and Bcl/xL activity. AZD0466 demonstrated superior anti-cancer activity in a wide range of preclinical tumour models including Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Non-Hodgkin’s Lymphoma and Small Cell Lung Cancer (SCLC).
DEP® docetaxel, DEP® cabazitaxel and DEP® irinotecan
The preclinical data presented in the two posters above comprise a series of xenograft studies showing enhanced efficacy of DEP® candidates/products used as a monotherapy or in combination with standard of care therapies.
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