By joining the drug to a dendrimer construct, very large increases in drug solubility have been achieved, which can enhance the “bioavailability” of the drug. 

For example Paclitaxel is a cancer drug well known for its poor aqueous solubility (<1μg/ml). When conjugated to a dendrimer construct a 9,000 fold increase in solublised Paclitaxel is achieved.

The structure is designed to release the active drug in the body so that it can achieve its intended pharmacological effects. 

Vial on the right:9,000x increase in water solubility

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