Traditionally, "well defined" complex macromolecules such as proteins were largely found only in natural systems. However, using Starpharma's dendrimer technology, it is possible to create precisely-defined synthetic complex macromolecules that are applicable to a wide range of medical uses.

One important property of dendrimers is “polyvalency” or the presence of multiple active groups on the surface of the dendrimer. This is significant because simultaneous presentation of active groups can yield entirely new or enhanced activity compared to single presentation of the same active group.

Starpharma's current development programs are in the areas of:

• HIV
• Genital herpes
• Other VivaGel^® indications such as HPV, bacterial vaginosis
  and Contraception
• Drug delivery
• siRNA delivery
• Other life science and industrial applications for dendrimers

The properties of Starpharma’s dendrimers make them suitable for pharmaceutical applications. For example, they are well defined chemical entities, which simplifies the regulatory process for their approval. They are also "biofriendly", being made predominantly from the amino acid, lysine.

For a more detailed overview, download the Dendrimer Overview Flyer.

For information on the use of dendrimers to create controlled macromolecular surfaces for your own applications, download the Macromolecule Surface Functionalisation Flyer.