Traditionally, "well defined" complex macromolecules such as proteins were primarily only found in natural systems. However, using Starpharma's dendrimer technology, it is possible to create precisely-defined synthetic complex macromolecules and macromolecular therapeutics that are applicable to a wide range of medical uses.

One important property of dendrimers is “polyvalency” or multiple active groups. By arranging multiple copies of an active group on the surface of the dendrimer a polyvalent effect can be achieved in biological systems. This is significant because simultaneous presentation of active groups can yield entirely new or enhanced activity compared to single presentation of the same active group.

Starpharma's current development programs focus on compounds with activity in disease areas that include:

•  HIV
•  Genital Herpes
•  Cancer
•  Ophthalmology
•  Contraception
•  Inflammation

Starpharma’s dendrimers have many properties that make them suitable for pharmaceutical applications. For example, they are well defined chemical entities, simplifying the regulatory process for their approval. They are also "biofriendly", being made predominantly from the naturally occurring amino acid, lysine.

For a more detailed overview, download the Dendrimer Overview Flyer.

For information on using dendrimers to create controlled macromolecular surfaces for your own applications, download the Macromolecule Surface Functionalisation Flyer.